ABSTRACT
Allergic bronchopulmonary aspergillosis(ABPA) is an inflammatory disease which causes a hypersensitivity to Aspergillus spores growing in the bronchi. The clinical syndrome is characterized by asthma, recurrent pulmonary infiltrations or mucoid impaction, eosinophilia, and central bronchiectasis. A 12-year-old boy was admitted to our hospital because of right lower chest pain and cystic mass-like shadows on a chest X-ray film. He had asthma as an infant, but had no asthmatic symptoms on admission. Chest CT scan showed low density cystic mass of the right lower lobe. The total eosinophil count and IgE level were abnormally high. Test for immediate skin reaction to Aspergillus fumigatus was positive but precipitating antibody to Aspergillus antigen was negative. After steroid treatment, he became asymptomatic. Radiologic abnormalities including mass-like shadows were resolved by two months after the start of treatment and a follow-up high resolution CT scan obtained after clinical improvement revealed central saccular bronchiectasis. We report one case of ABPA with review of literature.
Subject(s)
Child , Humans , Infant , Male , Aspergillosis, Allergic Bronchopulmonary , Aspergillus , Aspergillus fumigatus , Asthma , Bronchi , Bronchiectasis , Chest Pain , Eosinophilia , Eosinophils , Follow-Up Studies , Hypersensitivity , Immunoglobulin E , Skin , Spores , Thorax , Tomography, X-Ray Computed , X-Ray FilmABSTRACT
PURPOSE: Leptin is a protein encoded by the ob gene that is expressed in adipocytes. It regulates eating behavior by the action to the satiety centers in the hypothalamus. In ob/ob mouse, adipocytes can not produce leptin because of a mutation in the ob gene which results in obesity. Whereas, leptin concentrations were elevated in obese adults, and leptin levels in obese children has not been studied much until now. The purpose of this study is to evaluate leptin concentrations in obese children and to find out correlating factors with leptin. METHODS: Thirty-six obese childrens whose weight is above 97 percentile of korean weight standard and 39 children with average weight were included. Height, weight, waist to hip ratio, fat weight and lean body mass were measured. The serum levels of leptin, insulin, cholesterol and triglyceride were measured. RESULTS: Mean age was 10.8 +/- 2.5 years in obese group and 10.6 +/- 2.6 years in control group. Obesity percent was 51.6 +/- 18.8% in obese and 8.8 +/- 10.2% in control group. Body mass index (BMI) was 26.3 +/- 5.8kg/m2 in obese group and 17.3 +/- 1.9kg/m2 in control group. Leptin levels of obese group (13.7 +/- 5.4ng/ml) were significantly higher than that of the control group (3.6 +/- 3.3ng/ ml). Leptin levels showed no significant difference by gender and by pubertal development. Leptin levels significantly correlated with BMI, obesity percent, fat weight, and serum cholesterol level but showed no significant correlation with lean body mass, serum fasting insulin and triglyceride levels. CONCLUSION: Serum leptin levels of obesity group were significantly higher than that of the control group, and they were correlated with BMI, obesity percent and fat weight. Additional research is necessary to assess the mechanism of leptin resistance in obese children.
Subject(s)
Adult , Animals , Child , Humans , Mice , Adipocytes , Body Mass Index , Cholesterol , Fasting , Feeding Behavior , Hypothalamus , Insulin , Leptin , Obesity , Triglycerides , Waist-Hip RatioABSTRACT
PURPOSE: Leptin is a protein encoded by the ob gene that is expressed in adipocytes. It regulates eating behavior by the action to the satiety centers in the hypothalamus. In ob/ob mouse, adipocytes can not produce leptin because of a mutation in the ob gene which results in obesity. Whereas, leptin concentrations were elevated in obese adults, and leptin levels in obese children has not been studied much until now. The purpose of this study is to evaluate leptin concentrations in obese children and to find out correlating factors with leptin. METHODS: Thirty-six obese childrens whose weight is above 97 percentile of korean weight standard and 39 children with average weight were included. Height, weight, waist to hip ratio, fat weight and lean body mass were measured. The serum levels of leptin, insulin, cholesterol and triglyceride were measured. RESULTS: Mean age was 10.8 +/- 2.5 years in obese group and 10.6 +/- 2.6 years in control group. Obesity percent was 51.6 +/- 18.8% in obese and 8.8 +/- 10.2% in control group. Body mass index (BMI) was 26.3 +/- 5.8kg/m2 in obese group and 17.3 +/- 1.9kg/m2 in control group. Leptin levels of obese group (13.7 +/- 5.4ng/ml) were significantly higher than that of the control group (3.6 +/- 3.3ng/ ml). Leptin levels showed no significant difference by gender and by pubertal development. Leptin levels significantly correlated with BMI, obesity percent, fat weight, and serum cholesterol level but showed no significant correlation with lean body mass, serum fasting insulin and triglyceride levels. CONCLUSION: Serum leptin levels of obesity group were significantly higher than that of the control group, and they were correlated with BMI, obesity percent and fat weight. Additional research is necessary to assess the mechanism of leptin resistance in obese children.